权威研究:癌细胞就像吸血鬼,但现在,我们发现它有多种天敌

本研究示意图(图片来源:参考资料[5])

 

进一步分析显示,被吞掉的邻居会在衰老癌细胞的内部被送去特殊的消化装置——溶酶体。在那里,被吞噬的细胞分解,相当于提供了一场代谢物大餐。

研究者认为,癌细胞借助同类相食获取赖以生存的能量和物质,待到化疗结束还能引发肿瘤复发。基于这些发现,抑制这一过程,也许可以提供新的治疗机会。

参考资料:
[1] Robert D. Leone et al., (2019), Glutamine blockade induces pergent metabolic programs to overcome tumor immune evasion, Science, DOI: 10.1126/science.aav2588
[2] Revamped cancer drug starves tumors in mice, Retrieved November 7, 2019, from https://www.sciencemag.org/news/2019/11/revamped-cancer-drug-starves-tumors-mice
[3] Guillem Pascual-Pasto et al., (2019), Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01, Science Translational Medicine, DOI: 10.1126/scitranslmed.aat9321
[4] Crystal A. Tonnessen-Murray et al., (2019) Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival. Journal of Cell Biology DOI: http://doi.org/10.1083/jcb.201904051
[5] Michael Overholtzer (2019) Senescent cells feed on their neighbours. Nature. DOI: 10.1038/d41586-019-03271-3

注:本文旨在介绍医药健康研究进展,不是治疗方案推荐。如需获得治疗方案指导,请前往正规医院就诊。